Clemastinum [INN-Latin]

Clemastinum [INN-Latin] Brand names, Clemastinum [INN-Latin] Analogs

Clemastinum [INN-Latin] Brand Names Mixture

Xalacom (Latanoprost + Timolol Maleate)

Clemastinum [INN-Latin] Chemical_Formula

C₂₁H₂₆ClNO

Clemastinum [INN-Latin] RX_link

http://www.rxlist.com/cgi/generic3/clemast.htm

Clemastinum [INN-Latin] fda sheet

Clemastinum [INN-Latin] msds (material safety sheet)

Clemastinum_[INN-Latin] MSDS

Clemastinum [INN-Latin] Synthesis Reference

No information avaliable

Clemastinum [INN-Latin] Molecular Weight

343.89 g/mol

Clemastinum [INN-Latin] Melting Point

178 ^oC (hydrogen fumarate formulation)

Clemastinum [INN-Latin] H₂O Solubility

Soluble (hydrogen fumarate formulation)

Clemastinum [INN-Latin] State

Solid

Clemastinum [INN-Latin] LogP

5.789

Clemastinum [INN-Latin] Dosage Forms

Syrup (0.5 mg drug per 5mL syrup) and tablet (oral, 1mg)

Clemastinum [INN-Latin] Indication

For the relief of symptoms associated with allergic rhinitis such as sneezing, rhinorrhea, pruritus and acrimation.

Clemastinum [INN-Latin] Pharmacology

Clemastine is an antihistamine with anticholinergic (drying) and sedative side effects. Antihistamines competitively antagonize various physiological effects of histamine including increased capillary permeability and dilatation, the formation of edema, the "flare" and "itch" response, and gastrointestinal and respiratory smooth muscle constriction. Within the vascular tree, H1- receptor antagonists inhibit both the vasoconstrictor and vasodilator effects of histamine. Depending on the dose, H1- receptor antagonists can produce CNS stimulation or depression. Most antihistamines exhibit central and/or peripheral anticholinergic activity. Antihistamines act by competitively blocking H1- receptor sites. Antihistamines do not pharmacologically antagonize or chemically inactivate histamine, nor do they prevent the release of histamine.

Clemastinum [INN-Latin] Absorption

Rapidly absorbed from the gastrointestinal tract.

Clemastinum [INN-Latin] side effects and Toxicity

Oral LD₅₀ in rat and mouse is 3550 mg/kg and 730 mg/kg, respectively. Antihistamine overdosage reactions may vary from central nervous system depression to stimulation. In children, stimulation predominates initially in a syndrome which may include excitement, hallucinations, ataxia, incoordination, muscle twitching, athetosis, hyperthermia, cyanosis convulsions, tremors, and hyperreflexia followed by postictal depression and cardio-respiratory arrest. Convulsions in children may be preceded by mild depression. Dry mouth, fixed dilated pupils, flushing of the face, and fever are common. In adults, CNS depression, ranging from drowsiness to coma, is more common.

Clemastinum [INN-Latin] Patient Information